2nd Bachelor in Medical Biology - Cytology

Biochemistry

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ECTS Credits7
Number of Hours (h/year)75
Teaching staffBRUMIOUL, Dominique
DE RYCKER, C├ęcile
Course UnitCompulsory
TermQuad. 1 and 2
CodePARA-D_GBM0001/2
Prerequisite

Basic smattering of general and organic chemistry, of cell biology and main organs physiology.

Aims and Objectives

To provide the theoretical bases necessary to the laboratory analyses ( mainly in enzymology); to prepare the students for the pathology and medical chemistry lessons; to understand the importance and the variability of the laboratory tests.

Description

Protid’s : structure and physico-chemical properties ; technology of aminoacids identification and separation ; technology of proteins separation and purification.

Enzymology : definition, classification and mechanism of action; enzyme kinetics; enzymatic activity assay; coenzymes; enzymatic inhibitors; regulatory mechanisms.

Study of metabolisms :

· Bioenergetics (including respiratory chain and oxidative phosphorylation )

· Glucide metabolism: glycolysis ; pentoses phosphates shunt; glycogenesis and glycogenolysis; gluconeogenesis.

· The Krebs cycle

· Protid’s metabolism : aminoacids catabolism and anabolism; particular pathways.

· Lipids metabolism : lipoproteins ; fatty acids biosynthesis and catabolism ; triglycerides and complexes lipids biosynthesis; cholesterol metabolism; steroidal hormones and prostaglandins.

The blood : composition ; hemoglobin ( structure, properties and metabolism); respiratory function;

Acid-base balance : main buffer systems; physiological regulatory system; assessment parameters of balance and typing of diseases.

Bibliography

HARPER, Précis de Biochimie de Harper, Presses de l'Université Laval, 7ème Edition, 1989

MOUSSARD C., En bref, la biochimie, Ed. De Boeck, 1999.

RAWN J.D.,Traité de Biochimie, Ed. De Boeck Université, 1989

SCOPES R., Protein purification, Principles and Practice, Springer Verlag, 1982.

STRYER L., Stryer’s Biochemistry, W.H.Freeman, Oxford, 1995.

Teaching and Learning MethodsLectures
Assessment MethodsWritten examinations
Oral examinations
NotesIn part
LanguageFrench

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